Procedures & Techniques

Clinicians and healthcare providers are experiencing the world of Guerbet Interventional Radiology. Click on an asset to see how to use and understand our products.

Lipiodol^® Ultra-Fluid
(Iodinated ethyl esters of fatty acids of poppy seed oil)

HCC

Using Lipiodol^® Ultra-Fluid (Iodinated ethyl esters of fatty acids of poppy seed oil) in cTACE procedure

STANDARDIZATION IS KEY FOR REPRODUCIBLE AND OPTIMAL cTACE PROCEDURE

Learn how

Lipiodol^®-drug droplets are deformable & heterogeneous in size(1,2)

10 & 20µm Microscopic image

Lipiodol^{^®} + doxorubicin droplets

Droplet deformability

Extract of in vivo video microscopy of rat cremastervessels perfused with Lipiodol^{^®} - Courtesy of Prof. Th. de Baère

Droplet division

Extract of in vivo video microscopy of rat cremastervessels perfused with Lipiodol^{^®} - Courtesy of Prof. Th. de Baère

Lipiodol^®-drug droplets allow both proximal & distal anticancer drug delivery(1)

	Lipiodol^{^®} + anticancer agent
	Droplet deformability

Lipiodol^®-drug droplets achieve transient dual embolization (arterial & portal vessels)(3)

PV = Portal Venule
HA = Hepatic Arteriole
BD = Bile Duct
HV = Hepatic Venule
HC = Hepatocytes

Peribiliary plexa allow Lipiodol^®-Drug droplets shunting from hepatic artery to portal vein(4)

Radiological evidence of dual vascularization of HCC

GRADE 0

Arterial enhancement of the tumor

GRADE 1

Early venous enhancement thanks to the peribiliary vascular plexa

GRADE 2

Full visualization of the arterioportal vascular bed

Mechanism of Action

Thanks to its great physico-chemical & pharmacokinetic properties, Lipiodol^{^®} improves the efficiency of diversified indications.

Lipiodol^{^®} in cTACE: mechanism of action

Lipiodol^{^®} droplets are heterogeneous in size.⁽^{8, 15)}
Large & small droplets allow proximal & distal drug delivery into the tumor vascular system.
Lipiodol^{^®}-drug droplets have access to the tumor through the arterial vessels (red) and then to the portal venous system (blue).
Thanks to this dual vascularization, the drug is delivered in the whole tumor and can potentially reach the daughter ones.
At the end of Lipiodol^{^®}-drug administration, a complementary embolization is realized with gelatin foam.